Association of the Virus of Lymphocytic Choriomeningitis with Erythrocytes of Infected Animals.

The virus of lymphocytic choriomeningitis is found in organs and body fluids of infected man and animals [Rivers and Scott (1935, 1936), Armstrong, Wooley and Onstott (1936), Traub (1935, 1936a, c), Smadel and Wall (1941, 1942), Findlay and Stern (1936) and Kreis (1937)]. Traub (1936b) reported that the cellular sediment of leucocytes and erythrocytes from the blood of one out of four mice tested contained the virus. In attempts to determine whether the mechanism of transfer of the virus through the blood bears any relation to the pathogenesis of the disease the following observations were made: Erythrocytes from heparinized blood of infected mice and guinea pigs were separated from the silvery layer of leucocytes, washed 6-7 times in Locke solution